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Merck
CN

PHR1578

Trolamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Triethanolamine, 2,2′,2′′-Nitrilotriethanol, Tris(2-hydroxyethyl)amine

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About This Item

Linear Formula:
(HOCH2CH2)3N
CAS Number:
102-71-6
Molecular Weight:
149.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823486
EC Number:
203-049-8
Beilstein/REAXYS Number:
1699263
MDL number:
MFCD00002855

Key Documents

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InChI

1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2

InChI key

GSEJCLTVZPLZKY-UHFFFAOYSA-N

SMILES string

OCCN(CCO)CCO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. T2545000, traceable to USP 1696958

vapor density

5.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

API family

trolamine

CofA

current certificate can be downloaded

autoignition temp.

600 °F

expl. lim.

8.5 %

packaging

ampule of 5 mL

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

300

useful pH range

7.3-8.3

pKa (25 °C)

7.8

bp

190-193 °C/5 mmHg (lit.)

mp

17.9-21 °C (lit.)

density

1.124 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standard. Trolamine belongs to the family of ethanolamines, offering a broad spectrum of applications due to its ability to combine the properties of both amines and alcohols. Its property as an organic base to form soluble neutralization products with insoluble acids is reported.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2885 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

354.2 °F - closed cup

flash_point_c

179 °C - closed cup

Regulatory Information

监管及禁止进口产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Toxicology of Mono-, Di-, and Triethanolamine
Knaak BJ, et al.
Reviews of Environmental Contamination and Toxicology, 1-86 (1997)
The Preparation of Emulsions and Other Products with Triethanolamine N(C2H4OH)3, 1-86 (1933)

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