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PHR1640

Citalopram Hydrobromide

Name: Citalopram Hydrobromide
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Citalopram hydrobromide, 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

Empirical Formula (Hill Notation):

C₂₀H₂₁FN₂O · HBr

CAS Number:

59729-32-7

Molecular Weight:

405.30

EC Number:

261-890-6

MDL number:

MFCD02101306

PubChem Substance ID:

329823528

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 1153
traceable to Ph. Eur. Y0001008
traceable to USP 1134233

API family

citalopram

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Citalopram Hydrobromide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7789 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1134233

Citalopram hydrobromide, United States Pharmacopeia (USP) Reference Standard

1134244

1134222

1134197

1134288

1134266

1134255

1134277

1134299

PHR1906

PHR1863

PHR1902

PHR1904

PHR1903

BP1153

Citalopram hydrobromide, British Pharmacopoeia (BP) Reference Standard

PHR1905

PHR1901

BP1154

Citalopram impurity standard, British Pharmacopoeia (BP) Reference Standard

Pictograms

GHS07,GHS08

Signal Word

Warning

Hazard Statements

H302 - H336 - H361d - H412

Precautionary Statements

P201 - P273 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradation products and additives in pharmaceutical preparation.

Amer SM, et al.

Analytical Chemistry, 16(2), 53-62 (2016)

Spectrophotometric Determination of Citalopram Hydrobromide in Pharmaceuticals.

Narayana B and Veena K

Journal of the Mexican Chemical Society, 54(2), 98-102 (2010)

Citalopram prevents sleep-deprivation-induced reduction in CaMKII-CREB-BDNF signaling in mouse prefrontal cortex.

Afzal Misrani et al.

Brain research bulletin, 155, 11-18 (2019-11-20)

Curtailment of sleep in modern society leads to a spectrum of neuropsychiatric disorders. However, the molecular mechanisms underlying the effects of sleep deprivation (SD) remain elusive and currently there is no effective therapy to alleviate these effects. Here, we aimed

Development and Application of Spectrophotometric Methods for the Determination of Citalopram Hydrobromide in Dosage Forms.

Raza A

Chemical & Pharmaceutical Bulletin, 54(4), 432-434 (2006)

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