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Merck
CN

PHR1640

Citalopram Hydrobromide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Citalopram hydrobromide, 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C20H21FN2O · HBr
CAS Number:
59729-32-7
Molecular Weight:
405.30
NACRES:
NA.24
PubChem Substance ID:
329823528
UNSPSC Code:
41116107
EC Number:
261-890-6
MDL number:
MFCD02101306

Key Documents

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Product Name

Citalopram Hydrobromide, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

SMILES string

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001008
traceable to USP 1134233

API family

citalopram

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SLC6A4(6532)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Citalopram Hydrobromide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7789 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Afzal Misrani et al.
Brain research bulletin, 155, 11-18 (2019-11-20)
Curtailment of sleep in modern society leads to a spectrum of neuropsychiatric disorders. However, the molecular mechanisms underlying the effects of sleep deprivation (SD) remain elusive and currently there is no effective therapy to alleviate these effects. Here, we aimed
Development and Application of Spectrophotometric Methods for the Determination of Citalopram Hydrobromide in Dosage Forms.
Raza A
Chemical & Pharmaceutical Bulletin, 54(4), 432-434 (2006)
Spectrophotometric Determination of Citalopram Hydrobromide in Pharmaceuticals.
Narayana B and Veena K
Journal of the Mexican Chemical Society, 54(2), 98-102 (2010)
Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradation products and additives in pharmaceutical preparation.
Amer SM, et al.
Analytical Chemistry, 16(2), 53-62 (2016)

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