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Merck
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PHR1660

Indapamide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Indapamide, N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline

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About This Item

Empirical Formula (Hill Notation):
C16H16ClN3O3S
CAS Number:
26807-65-8
Molecular Weight:
365.83
NACRES:
NA.24
PubChem Substance ID:
329823538
UNSPSC Code:
41116107
EC Number:
248-012-7
MDL number:
MFCD00079375

Key Documents

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InChI

1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

InChI key

NDDAHWYSQHTHNT-UHFFFAOYSA-N

SMILES string

CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(N)(=O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0150000, traceable to USP 1338801

API family

indapamide

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SLC12A3(6559)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Indapamide is a diuretic that is categorized under the family of benzothiadiazines compounds. It is an oral drug that is usually prescribed as an antihypertensive agent for patients with mild to moderate hypertension.

Application

Indapamide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Lact. - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Quantitative determination of indapamide in pharmaceuticals and urine by high-performance liquid chromatography with amperometric detection.
Legorburu MJ, et al.
Journal of Chromatographic Science, 37(8), 283-287 (1999)
Determination of certain drugs in binary mixtures formulations by second derivative ratio spectrophotometry and LC.
El-Gindy A, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 59(9), 703-712 (2004)
Development of new spectrophotometric methods for the determination of Indapamide in bulk and Pharmaceutical formulations.
Pai JB, et al.
International Journal of ChemTech Research, 3(2), 755-760 (2011)
Comparison of spectrophotometric and an LC method for the determination perindopril and indapamide in pharmaceutical formulations.
Erk N
Journal of Pharmaceutical and Biomedical Analysis, 26(1), 43-52 (2001)

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