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PHR1665

Supelco

Chlorobenzene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Chlorobenzene
Empirical Formula (Hill Notation):
C6H5Cl
CAS Number:
Molecular Weight:
112.56
Beilstein:
605632
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

3.86 (vs air)

vapor pressure

11.8 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

1178 °F

expl. lim.

7.1 %

packaging

ampule of 3x1.2 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.524 (lit.)

bp

132 °C (lit.)

mp

−45 °C (lit.)

density

1.106 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1601361

storage temp.

2-30°C

SMILES string

Clc1ccccc1

InChI

1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H

InChI key

MVPPADPHJFYWMZ-UHFFFAOYSA-N

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General description

Chlorobenzenes find use in domestic as well as industrial applications such as solvents, degreasers, pesticides and chemical intermediates for the synthesis of various chemical compounds. They are regarded as environmental pollutants because of their hazardous nature.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Chlorobenzene may be used as a reference organic solvent standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1691 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

80.6 °F

Flash Point(C)

27 °C

Certificate of Analysis

Certificate of Origin

Optimization of temperature-controlled ionic liquid dispersive liquid phase microextraction combined with high performance liquid chromatography for analysis of chlorobenzenes in water samples
Kamarei F, et al.
Talanta, 83(1), 36-41 (2010)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)

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