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Merck
CN

PHR1665

Chlorobenzene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Chlorobenzene

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About This Item

Empirical Formula (Hill Notation):
C6H5Cl
CAS Number:
108-90-7
Molecular Weight:
112.56
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823541
EC Number:
203-628-5
Beilstein/REAXYS Number:
605632
MDL number:
MFCD00000530

Key Documents

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InChI key

MVPPADPHJFYWMZ-UHFFFAOYSA-N

InChI

1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H

SMILES string

Clc1ccccc1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1601361

vapor density

3.86 (vs air)

vapor pressure

11.8 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

1178 °F

expl. lim.

7.1 %

packaging

ampule of 3x1.2 mL

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.524 (lit.)

Quality Level

300

mp

−45 °C (lit.)

density

1.106 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Chlorobenzenes find use in domestic as well as industrial applications such as solvents, degreasers, pesticides and chemical intermediates for the synthesis of various chemical compounds. They are regarded as environmental pollutants because of their hazardous nature.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorobenzene may be used as a reference organic solvent standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC1691 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

80.6 °F

flash_point_c

27 °C

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Optimization of temperature-controlled ionic liquid dispersive liquid phase microextraction combined with high performance liquid chromatography for analysis of chlorobenzenes in water samples
Kamarei F, et al.
Talanta, 83(1), 36-41 (2010)
Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)

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