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PHR1689

Ammonium Glycyrrhizate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Glycyrrhizic acid ammonium salt

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About This Item

Empirical Formula (Hill Notation):
C42H62O16 · NH3
CAS Number:
53956-04-0
Molecular Weight:
839.96
NACRES:
NA.24
PubChem Substance ID:
329823557
UNSPSC Code:
41116107
EC Number:
258-887-7
MDL number:
MFCD00167400

Key Documents

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InChI key

ILRKKHJEINIICQ-OOFFSTKBSA-N

InChI

1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1

SMILES string

N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. G0460000, traceable to USP 1029929

API family

glycyrrhizic acid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ammonium Glycyrrhizate is the ammonium salt of glycyrrhizic acid (GA), an important ingredient in the liquorice root with a broad-spectrum of biological and pharmacological properties.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3160 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ammonium Glycyrrhizate : A comprehensive review of its Traditional use, phytochemistry, pharmacology and safety
Gupta T and Mujeeb M
Asian Journal of Pharmaceutical Education and Research, 7(1) (2018)

Articles

Determination of Glycyrrhizic Acid Honokiol and Magnolol

Quantitative HPLC-UV analysis of honokiol, magnolol, and glycyrrhizic acid in Huoxiang Zhengqi Shui following the Chinese Pharmacopoeia draft.

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