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PHR1733

Escitalopram Oxalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Escitalopram oxalate, S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate, S-(+)-Citalopram oxalate

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About This Item

Empirical Formula (Hill Notation):
C20H21FN2O · C2H2O4
CAS Number:
219861-08-2
Molecular Weight:
414.43
NACRES:
NA.24
PubChem Substance ID:
329823581
UNSPSC Code:
41116107
MDL number:
MFCD06407826
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001796, traceable to USP 1249406

API family

escitalopram

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

InChI key

KTGRHKOEFSJQNS-BDQAORGHSA-N

Gene Information

human ... SLC6A4(6532)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Escitalopram Oxalate, a highly selective serotonin re-uptake inhibitor antidepressant, is a pure S-enantiomer of the racemic, bicyclic pthalates derivatives of citalopram. It is mainly developed for the treatment of depression and anxiety disorders.

Application

Escitalopram Oxalate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance thin layer chromatography technique and reversed-phase high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI); the S-enantiomer and eutomer of citalopram.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2085 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stability-indicating RP-HPLC method for the simultaneous determination of escitalopram oxalate and clonazepam.
Kakde B R, et al.
Journal of Chromatographic Science, 51(6), 490-495 (2012)
Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets.
Dhavale N, et al.
Chromatographia, 67(5-6), 487-490 (2008)
Development and validation of an RP-HPLC method for the simultaneous determination of Escitalopram Oxalate and Clonazepam in bulk and its pharmaceutical formulations
Bhimanadhuni NC, et al.
International Current Pharmaceutical Journal, 1(8), 193-198 (2012)
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1733-1G04061834802112