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PHR1744

3-Chlorobenzoic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3-Chlorobenzoic acid

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About This Item

Linear Formula:
ClC6H4CO2H
CAS Number:
535-80-8
Molecular Weight:
156.57
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823589
EC Number:
208-618-4
Beilstein/REAXYS Number:
907218
MDL number:
MFCD00002491

Key Documents

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SMILES string

OC(=O)c1cccc(Cl)c1

InChI

1S/C7H5ClO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,(H,9,10)

InChI key

LULAYUGMBFYYEX-UHFFFAOYSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1112299

API family

bupropion

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

300

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

3-Chlorobenzoic acid may be used as a pharmaceutical reference standard for the determination of the analyte in bulk powders and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7967 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kinetic study and peak purity determination of bupropion hydrochloride using RRLC/DAD and HPLC/MWD methods: stability study and application in pharmaceutical preparation and in synthetic mixtures with nicotine
El-Kosasy AM, et al.
Royal Society of Chemistry Advances, 5(79), 64274-64285 (2015)
Stability indicating HPLC and spectrophotometric methods for the determination of bupropion hydrochloride in the presence of its alkaline degradates and related impurity
Abbas SS, et al.
Bulletin of Faculty of Pharmacy, Cairo University , 50(1), 49-59 (2012)

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