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Merck
CN

PHR1792

Fluphenazine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Fluphenazine dihydrochloride, 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H26F3N3OS · 2HCl
CAS Number:
146-56-5
Molecular Weight:
510.44
NACRES:
NA.24
PubChem Substance ID:
329823616
UNSPSC Code:
41116107
EC Number:
205-674-1
MDL number:
MFCD00055212

Key Documents

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Product Name

Fluphenazine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

SMILES string

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. F0280000
traceable to USP 1282004

API family

fluphenazine

form

powder

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... DRD2(1813)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Biochem/physiol Actions

D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8814 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Fluphenazine Hydrochloride can be used as a reference standard to construct a calibration curve for quantifying the drug in injectable formulations using HPTLC. It is also used for the determination of analyte in antidepressant mixture pharmaceutical form.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H360

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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