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PHR1799

Meloxicam

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Meloxicam, 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C14H13N3O4S2
CAS Number:
71125-38-7
Molecular Weight:
351.40
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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InChI

1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,19H,1-2H3,(H,15,16)/b13-11+

InChI key

DWMREKMVXIFPFM-ACCUITESSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1379401, traceable to Ph. Eur. Y0001080

API family

meloxicam

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

This pharmaceutical secondary standard can also be used as follows:

  • Development of three spectrophotometric methods to determine meloxicam in its pharmaceutical formulations
  • Voltammetric determination of meloxicam in pharmaceutical formulations using a boron-doped diamond electrode (BDDE)
  • High-performance liquid chromatography-based quantitative analysis of meloxicam in its different tablet formulations
  • Development and validation of a reversed-phase HPLC method for the separation and estimation of meloxicam in its pharmaceutical dosage forms
  • Quantification of meloxicam and piroxicam from plasma samples using a liquid chromatography method combined with UV detection

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Meloxicam is an oxicam derivative and belongs to the group of non-steroidal anti-inflammatory drugs (NSAID), used for its analgesic, anti-inflammatory, and antipyretic properties. It acts by inhibiting the activity of prostaglandin synthetase, thereby preventing the synthesis of prostaglandins and decreasing inflammation.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAB7807 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode
Selesovska R, et al.
Journal of Electroanalytical Chemistry, 858, 113758-113758 (2020)
Spectrophotometric estimation of meloxicam in bulk and its pharmaceutical formulations
Dhandapani B, et al.
International Journal of Pharma Sciences and Research, 1, 217-221 (2010)
High-performance liquid chromatography determination of meloxicam and piroxicam with ultraviolet detection
Cox S, et al.
Chromatography Research International, 2014 (2014)
Reverse phase HPLC method development and validation for determination of Meloxicam in bulk and pharmaceutical formulation
Shaji J and Jain V
International Journal of Pharmaceutical Sciences and Research, 2, 107-107 (2011)
Specific and simple hplc assay of ecofriendly meloxicam in pharmaceutical formulations
Mahmood KT, et al.
Journal of Pharmaceutical Sciences and Research, 2, 878-878 (2010)
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