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PHR1800

Metamizole Sodium

Name: Metamizole Sodium
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Metamizole sodium hydrate, (antipyrinylmethylamino)methanesulfonic acid sodium salt, 1-Phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate sodium, 4-Methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone sodium methanesulfonate, Analgin, Dipyrone, Metamizol, Methampyrone, Methylmelubrin, Noraminopyrine methanesulfonate sodium, Sodium methylaminoantipyrine methanesulfonate, Sulpyrine, [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₆N₃O₄S · Na · H₂O

CAS Number:

5907-38-0

Molecular Weight:

351.35

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. M0600900

API family

metamizole

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 100 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical
pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

[Na+].[S](=O)(=O)([O-])CN(C)c1[c]([n]([n](c1C)C)c2ccccc2)=O.O

InChI

1S/C13H17N3O4S.Na.H2O/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;;/h4-8H,9H2,1-3H3,(H,18,19,20);;1H2/q;+1;/p-1

InChI key

UNZIDPIPYUMVPA-UHFFFAOYSA-M

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Metamizole (Dipyrone) is a potent analgesic and antipyretic.

Metamizole (Dipyrone) is a potent analgesic and antipyretic. Metamizole inhibits prostaglandin synthesis in both the periphery and the central nervous system. Metamizole may act as a prodrug. It is rapidly hydrolyzed to N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA) which inhibit cyclo-oxygenase activity and can be further acylated with arachidonic acid forming compounds that bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors. It is believed that these metabolites play a major role in metamizole activity. Metamizole has been withdrawn from clinical use in several countries because of a side-effect of agranulocytosis in some patients.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC2806 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Pictograms

GHS08

Signal Word

Warning

Hazard Codes

H361fd

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)