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PHR1867

Rivastigmine Hydrogen Tartrate

Name: Rivastigmine Hydrogen Tartrate
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Rivastigmine tartrate, ENA-713, Ethylmethyl-carbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, N-Ethyl-N-methyl-carbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester tartrate, S-Rivastigmine tartrate

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂N₂O₂· C₄H₆O₆

CAS Number:

129101-54-8

Molecular Weight:

400.42

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical secondary standard, certified reference material

Quality Segment

300

agency

traceable to Ph. Eur. Y0001516, traceable to USP 1604858

API family

rivastigmine

form

powder

CofA

current certificate can be downloaded

packaging

pkg of 1 g

application(s)

pharmaceutical

storage temp.

2-8°C

SMILES string

N([C@@H](C)c1cc(ccc1)OC(=O)N(CC)C)(C)C.O[C@@H]([C@H](O)C(=O)O)C(=O)O

InChI

1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m00/s1

InChI key

GWHQHAUAXRMMOT-RWALOXMOSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Rivastigmine is an orally available, brain penetrant, reversible cholinesterase inhibitor that enhances cognitive function in patients with Alzheimer′s and Parkinson′s diseases. Rivastigmine inhibits both butyrylcholinesterase and acetylcholinesterase.

Rivastigmine is an orally available, brain penetrant, reversible cholinesterase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB1259 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Pictograms

GHS06,GHS09

Signal Word

Danger

Hazard Codes

H300,H411

Precautionary Statements

P264 - P270 - P273 - P301 + P310 - P391 - P405

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)