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PHR1883

Docetaxel

Name: Docetaxel
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Docetaxel trihydrate

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About This Item

Empirical Formula (Hill Notation):

C₄₃H₅₃NO₁₄ · 3H₂O

CAS Number:

148408-66-6

Molecular Weight:

861.93

UNSPSC Code:

41116107

NACRES:

NA.24

eCl@ss:

25140904

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Properties

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001133, traceable to USP 1224551

API family

docetaxel

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

N([C@H]([C@@H](O)C(=O)O[C@H]2C[C@]3([C@H]([C@@H]5[C@]6([C@H](OC6)C[C@@H]([C@]5(C(=O)[C@@H](C(=C2C)C3(C)C)O)C)O)OC(=O)C)OC(=O)c4ccccc4)O)c1ccccc1)C(=O)OC(C)(C)C.O.O.O

InChI

1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1

InChI key

XCDIRYDKECHIPE-QHEQPUDQSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Docetaxel is a taxoid anticancer agent that binds to β tubulin and promotes tubulin assembly into microtubles inducing cell-cycle arrest and apoptosis.

Application

Docetaxel may be used as a pharmaceutical reference standard for the determination of the analyte in plasma samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB0750 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Pictograms

GHS08,GHS07

Signal Word

Danger

Hazard Codes

H319,H360F

Precautionary Statements

P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)