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PHR1890

Supelco

Tiotropium bromide monohydrate

Pharmaceutical Secondary Standard; Certified Reference Material

Empirical Formula (Hill Notation):
C19H22BrNO4S2 · H2O
CAS Number:
Molecular Weight:
490.43

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical

format

neat

pharmacopeia traceability

traceable to PhEur Y0001188

storage temp.

2-8°C

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Tiotropium bromide monohydrate is structurally related to ipratropium bromide. It is a second-generation anticholinergic agent specific for muscarinic receptors (M1, M2 & M3) in humans.

Application

Tiotropium bromide monohydrate may be used as a reference compound to investigate the role of M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0347 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
Brown S M, et al.
European Journal of Pharmacology, 702(1-3), 109-115 (2013)

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