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Merck
CN

S6387

Sulfadiazine sodium salt

≥98% (HPLC)

Synonym(s):

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide sodium salt, SPS Agar Supplement

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About This Item

Empirical Formula (Hill Notation):
C10H9N4NaO2S
CAS Number:
547-32-0
Molecular Weight:
272.26
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329824562
EC Number:
208-919-0
Beilstein/REAXYS Number:
4068213
MDL number:
MFCD00067333

Key Documents

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InChI key

JLDCNMJPBBKAHH-UHFFFAOYSA-N

InChI

1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

SMILES string

Nc1ccc(cc1)S(=O)(=O)N([Na])c2ncccn2

grade

analytical standard

assay

≥98% (HPLC)

form

crystalline powder

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Quality Level

100

Related Categories

General description

Sulfadiazine sodium salt is a broad-spectrum antibiotic belonging to the class of sulfonamides commonly used against gram-postive and gram-negative microorganisms in humans and veterinary medication. Its mode of action involves inhibiting the multiplication of bacteria as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadiazine may be used as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography technique.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000430824
0000430824
0000359049
0000359048
0000252608

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Drugs: Synonyms and Properties (2017)
Eco-toxic effects of sulfadiazine sodium, sulfamonomethoxine sodium and enrofloxacin on wheat, Chinese cabbage and tomato
Ecotoxicology (London, England), 18(7), 878-885 (2009)
High-performance liquid chromatographic method for determination of sulfapyridine in human saliva using post-column, in-line derivatization with fluorescamine
Sista.S.H, et al.
Journal of Chromatography. B, Biomedical Applications, 273(2), 103-106 (1983)
Chun-Xue Zhou et al.
Antimicrobial agents and chemotherapy, 63(10) (2019-08-07)
In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally with SDZ
Vanessa Estato et al.
The American journal of pathology, 188(11), 2674-2687 (2018-08-20)
Toxoplasmosis is one of the leading parasitic diseases worldwide. Some data suggest that chronic acquired toxoplasmosis could be linked to behavioral alterations in humans. The parasite infects neurons, forming immunologically silent cysts. Cerebral microcirculation homeostasis is determinant to brain functions
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