SMB00947
N-Desethyl amodiaquine dihydrochloride
≥95%
Synonym(s):
Monodesethylamodiaquine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C18H18ClN3O · 2HCl
CAS Number:
Molecular Weight:
400.73
NACRES:
NA.77
UNSPSC Code:
41116107
Assay:
≥95%
Form:
solid
biological source
synthetic
Quality Segment
assay
≥95%
form
solid
mol wt
400.73 g/mol
technique(s)
HPLC: suitable
color
yellow to dark yellow
solubility
DMSO: soluble, methanol: soluble, water: soluble
storage temp.
2-8°C
Application
Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research
Other Notes
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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