biological source
synthetic
Quality Segment
assay
≥95%
form
solid
mol wt
400.73 g/mol
technique(s)
HPLC: suitable
color
yellow to dark yellow
solubility
DMSO: soluble, methanol: soluble, water: soluble
storage temp.
2-8°C
Application
Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable