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SMB00963

Desethylchloroquine

research grade, ≥95% (HPLC)

Synonym(s):

7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline, 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline, N-Desethyl chloroquine, N-Desethylchloroquine, N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine, Monodeethylchloroquine, Monodesethylchloroqu​ine

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About This Item

Empirical Formula (Hill Notation):
C16H22ClN3
CAS Number:
1476-52-4
Molecular Weight:
291.82
UNSPSC Code:
41116107
NACRES:
NA.77
MDL number:
MFCD00871808
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biological source

synthetic

Quality Segment

200

assay

≥95% (HPLC)

form

powder or crystals

technique(s)

HPLC: suitable

color

white to off-white

shipped in

wet ice

storage temp.

2-8°C

SMILES string

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

General description

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.

Application

Application: Metabolomics research

Other Notes

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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