SMB00975
Bisdesethylchloroquine Hydrochloride
Synonym(s):
Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C14H18ClN3 · xHCl
Molecular Weight:
263.77 (free base basis)
UNSPSC Code:
41116105
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
assay
≥95% (HPLC)
Quality Segment
form
solid
storage temp.
2-8°C
SMILES string
Clc1cc2nccc(c2cc1)NC(CCCN)C
InChI
1S/C14H18ClN3/c1-10(3-2-7-16)18-13-6-8-17-14-9-11(15)4-5-12(13)14/h4-6,8-10H,2-3,7,16H2,1H3,(H,17,18)
InChI key
GYEDIFVVTRKXHP-UHFFFAOYSA-N
General description
Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.
Application
Metabolomics research
Other Notes
For additional information on our range of Biochemicals, please complete this form.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.