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Merck
CN

T0781

3,5,5,-Trimethyloxazolidine-2,4-dione

analytical standard

Synonym(s):

Trimethadione

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About This Item

Empirical Formula (Hill Notation):
C6H9NO3
CAS Number:
127-48-0
Molecular Weight:
143.14
NACRES:
NA.24
PubChem Substance ID:
329826621
UNSPSC Code:
41116107
EC Number:
204-845-8
MDL number:
MFCD00047084

Key Documents

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InChI key

IRYJRGCIQBGHIV-UHFFFAOYSA-N

InChI

1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3

SMILES string

CN1C(=O)OC(C)(C)C1=O

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

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Matthew E Barton et al.
European journal of pharmacology, 521(1-3), 79-85 (2005-09-21)
The purpose of the present study was to explore the analgesic effects of the low voltage-activated T-type Ca2+ channel blockers ethosuximide, trimethadione, and mibefradil in persistent and acute nociceptive tests. The anticonvulsant effects of the compounds were also determined in
James J Collins et al.
Experimental gerontology, 41(10), 1032-1039 (2006-07-29)
The identification and analysis of compounds that delay aging and extend lifespan is an important aspect of gerontology research; these studies can test theories of aging, lead to the discovery of endogenous systems that influence aging, and establish the foundation
E Tanaka et al.
Journal of clinical pharmacy and therapeutics, 28(6), 493-496 (2003-12-04)
Trimethadione (TMO), an antiepileptic drug, may be used as a candidate for estimating hepatic drug-oxidizing activity. While TMO metabolism is mainly catalysed by CYP2C9, CYP2E1 and CYP3A4 the contribution of the different isoforms is unclear. In this study, we determined
N Kurata et al.
Xenobiotica; the fate of foreign compounds in biological systems, 28(11), 1041-1047 (1999-01-08)
1. Caucasian liver samples were used in this study. N-demethylation of trimethadione (TMO) to dimethadione (DMO) was monitored in the presence of chemical inhibitors of CYPs, such as fluconazole, quinidine, dimethyl-nitrosamine, acetaminophen, phenacetin, chlorzoxazone and mephenytoin. Trimethadione N-demethylation was selectively
Tammye L Fleeman et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 71(3), 185-190 (2004-07-30)
Congenital membranous ventricular septal defects (VSD) have been shown to close during postnatal development in rats [Solomon et al., Teratology 55:185-194, 1997]. Although they may differ in size, spontaneous and treatment-related VSD are histologically similar; however, the postnatal fate of
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