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T0891

Supelco

Tolbutamide

analytical standard

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Synonym(s):
1-Butyl-3-(4-methylphenylsulfonyl)urea, N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
Empirical Formula (Hill Notation):
C12H18N2O3S
CAS Number:
64-77-7
Molecular Weight:
270.35
Beilstein:
1984428
EC Number:
200-594-3
MDL number:
MFCD00027169
PubChem Substance ID:
329826629

biological source

synthetic (organic)

Quality Level

200

grade

analytical standard

Assay

97.0-103.0%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

ethanol: 50 mg/mL, clear, colorless

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

InChI key

JLRGJRBPOGGCBT-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , ALB(213) , CYP1A2(1544) , CYP2C9(1559) , EPHX2(2053) , KCNJ1(3758) , KCNJ11(3767)
mouse ... Ephx2(13850)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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The human liver cell line HepaRG has been recognized as a promising source for in vitro testing of metabolism and toxicity of compounds. However, currently the hepatic differentiation of these cells relies on exposure to dimethylsulfoxide (DMSO), which, as a
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