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T5411

Supelco

Testosterone solution

1.0 mg/mL in 1,2-dimethoxyethane, drug standard

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CAS Number:
58-22-0
Beilstein:
1915399
MDL number:
MFCD00003654
PubChem Substance ID:
329826822
NACRES:
NA.24

grade

drug standard

Quality Level

200

drug control

Home Office Schedule 4.2

concentration

1.0 mg/mL in 1,2-dimethoxyethane

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@H](O)CC[C@@]24[H]

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Gene Information

human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

41.0 °F - closed cup

Flash Point(C)

5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Julia K Slezak et al.
Scientific reports, 7(1), 17636-17636 (2017-12-17)
The concentrations of testosterone deposited in hair during hair growth may provide a retrospective reflection of the concentrations of bioactive testosterone in plasma. The objective of this study was to develop a radioimmunoassay with a sufficiently low limit of detection
Jenny Roy et al.
Bioorganic & medicinal chemistry, 15(8), 3003-3018 (2007-03-06)
In our efforts to develop compounds with therapeutic potential as antiandrogens, we synthesized a series of 5alpha-androstane-3alpha,17beta-diol derivatives with a fixed side-chain length of 3-methylenes at C-16alpha, but bearing a diversity of functional groups at the end. Among these, the
Annu A Söderholm et al.
Journal of medicinal chemistry, 48(4), 917-925 (2005-02-18)
We studied the three-dimensional quantitative structure-activity relationships (3D QSAR) of 70 structurally and functionally diverse androgen receptor (AR) binding compounds using the comparative molecular similarity indices analysis (CoMSIA) method. The compound set contained 67 nonsteroidal analogues of flutamide, nilutamide, and
Arjan van Oeveren et al.
Journal of medicinal chemistry, 49(21), 6143-6146 (2006-10-13)
The androgen receptor is a member of the extended family of nuclear receptors and is widely distributed throughout the body. Androgen therapy is used to compensate for low levels of the natural hormones testosterone (T) and dihydrotestosterone and consists of
Line Cantin et al.
The Journal of biological chemistry, 282(42), 30910-30919 (2007-08-23)
Antiandrogens are commonly used to treat androgen-dependent disorders. The currently used drugs unfortunately possess very weak affinity for the human AR (hAR), thus indicating the need to develop new high-affinity steroidal antiandrogens. Our compounds are specially designed to impede repositioning
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