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Merck
CN

T6159

Trimebutine

analytical standard

Synonym(s):

3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester

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About This Item

Empirical Formula (Hill Notation):
C22H29NO5
CAS Number:
39133-31-8
Molecular Weight:
387.47
EC Number:
254-309-2
MDL number:
MFCD00133873
UNSPSC Code:
41116107
PubChem Substance ID:
329826841
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c2ccccc2

InChI

1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3

InChI key

LORDFXWUHHSAQU-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Kwan Hyung Cho et al.
International journal of pharmaceutics, 400(1-2), 145-152 (2010-09-10)
To develop a novel combination tablet which contained 100 mg trimebutine maleate and 5 mg mosapride citrate (TMCT) for the treatment of functional dyspepsia, the wet granulation method was used to prepare TMCTs with various amounts of diluents and stabilizers.
Toru Hiyama et al.
Journal of gastroenterology and hepatology, 22(10), 1566-1570 (2007-09-12)
Functional dyspepsia (FD) is often treated with serotonin agonists; however, the efficacy of such agents has recently been questioned. The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) comparing serotonin agonists with other types
Imke Masuy et al.
Alimentary pharmacology & therapeutics, 49(9), 1134-1172 (2019-03-30)
Functional dyspepsia, consisting of epigastric pain syndrome and postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are available and conflicting results in terms of efficacy have been reported. Consequently, nonpharmacological treatment options are
[Trimebutine. Pharmacology, recent concepts about its mechanism of action, therapeutic results].
B Fraitag et al.
Gastroenterologie clinique et biologique, 16(5), 413-420 (1992-01-01)
A V Krymchantowski et al.
Cephalalgia : an international journal of headache, 26(7), 871-874 (2006-06-17)
Gastroparesis frequently happens during migraine attacks, postponing the onset of action of orally administered drugs. Furthermore, triptans seem to work better in the earlier phases of the migraine attacks. Therefore, associating a gastrokinetic drug with a triptan may translate into
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