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Merck
CN

T7511

Tripelennamine hydrochloride

analytical standard

Synonym(s):

2-(Benzyl[2-dimethylaminoethyl]amino)pyridine, N-Benzyl-N′,N′-dimethyl-N-(2-pyridyl)ethylenediamine hydrochloride, Pyribenzamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H21N3 · HCl
CAS Number:
154-69-8
Molecular Weight:
291.82
NACRES:
NA.24
PubChem Substance ID:
329826868
UNSPSC Code:
41116107
EC Number:
205-833-5
MDL number:
MFCD00012815

Key Documents

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Product Name

Tripelennamine hydrochloride, analytical standard

InChI key

FSSICIQKZGUEAE-UHFFFAOYSA-N

InChI

1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

SMILES string

CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2.Cl

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

Gene Information

human ... HRH1(3269)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tripelennamine hydrochloride may be used as a reference standard in the determination of tripelennamine hydrochloride in samples of animal feed by gas chromatography (GC) method, wastewater and urine using high performance liquid chromatography (HPLC) method employing fluorescence detector.

General description

Tripelennamine hydrochloride is an antihistamine drug, which is used in the treatment of bronchitis, asthma and bronchoconstriction.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8607
MKCV4290
MKCK8141
MKCH2831
MKBV5910V

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Trace determination of the antihistamines tripelennamine hydrochloride, thenyldiamine hydrochloride, and chlorothen citrate in admixture in animal feed, human urine, and wastewater by high-pressure liquid chromatography and use of a fluorescence detector.
Thompson TH, et al.
Talanta, 30(4), 251-260 (1983)
S Sekizawa et al.
Respiration physiology, 112(1), 13-22 (1998-08-08)
The response to histamine of nasal afferents has been studied in guinea pigs by recording the electrical activity of the whole ethmoidal nerve (EN) or that of single units. Guinea pigs were anaesthetized with urethane and breathed through a tracheostomy.
C E Johanson et al.
Experimental and clinical psychopharmacology, 6(4), 427-432 (1998-12-23)
Participants discriminated between tripelennamine and placebo in experiments differing in instructional set. In 1 experiment (SED), participants were told that 1 of the 2 drugs was more sedative-like, and during the other (STIM), 1 was more stimulant-like. During generalization tests
G Viola et al.
Die Pharmazie, 59(12), 948-951 (2005-01-11)
The influence of mast cell activation on the secretion of prolactin has been studied in rats receiving lysophosphatidylserine, a natural occurring phospholipid with secretagogue activity in these cells. After the i.v. injection of lysophosphatidylserine (10 mg/kg) a plasma prolactin peak
Y Xia et al.
European journal of pharmacology, 316(1), 81-85 (1996-11-28)
Effects of histamine and related agonists and antagonists on formation of cAMP were determined for enzymatically dissociated ganglia from the myenteric plexus of the guinea-pig small intestine. Formation of cAMP was stimulated by histamine in both dose- and time-dependent manners.
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