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T8656

Sigma-Aldrich

Thiourea

ACS reagent, ≥99.0%

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Synonym(s):
Sulfourea, Thiocarbamide
Linear Formula:
NH2CSNH2
CAS Number:
62-56-6
Molecular Weight:
76.12
Beilstein:
605327
EC Number:
200-543-5
MDL number:
MFCD00008067
PubChem Substance ID:
24900549

grade

ACS reagent

Quality Level

200

Assay

≥99.0%

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 105°C, 2h

mp

170-176 °C (lit.)
174-177 °C

solubility

H2O: passes test

SMILES string

NC(N)=S

InChI

1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

InChI key

UMGDCJDMYOKAJW-UHFFFAOYSA-N

Gene Information

mouse ... Ephx2(13850)

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General description

Thiourea is an analogue of urea containing sulphur.

Application

Thiourea has been used:
  • as a component of lysis buffer for liver tissue homogenization
  • in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
  • in rehydration buffer for protein extraction

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches
Gupta YR, et al.
Aquaculture and Fisheries, 1(2), 15-23 (2016)
Investigation of protein-tyrosine phosphatases by in-gel assays.
Markova B, et al.
Methods, 35(1), 22-27 (2005)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
Shrinivas Venkataraman et al.
Macromolecular rapid communications, 34(8), 652-658 (2013-03-14)
Readily water-soluble PEGylated amphiphiles containing bis-thiourea-based molecular recognition units at the interface of hydrophobic and hydrophilic blocks are developed. Self-assembly of these amphiphiles is found to be dependent on the exact chemical composition of the hydrophobic component. Elongated, spherical, and
Mireille Vonlanthen et al.
The Journal of organic chemistry, 78(8), 3980-3988 (2013-03-09)
Proof that sulfur is a viable reporting element for the development of fluorescent chemosensors for metal ions is presented. To date, the majority of metal-responsive fluorescent chemosensors have relied on metal-nitrogen coordination to provide a fluorescence response, most commonly by
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