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X114

Triton™ X-114

laboratory grade

Synonym(s):

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol, Polyethylene glycol tert-octylphenyl ether

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About This Item

Linear Formula:
(C2H4O)n C14H22O, n = 7 or 8
CAS Number:
9036-19-5
UNSPSC Code:
12161900
NACRES:
NA.21
PubChem Substance ID:
24902129
MDL number:
MFCD00128254
Beilstein/REAXYS Number:
2315025
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grade

laboratory grade

Quality Level

200

description

non-ionic

mol wt

average mol wt 537

composition

t-Oct-C6H4-(OCH2CH2)xOH, x = 7-8

refractive index

n20/D 1.488 (lit.)

CMC

0.2 mM (20-25°C)

transition temp

pour point ~−9 °C, cloud point 23 °C

HLB

12.4

SMILES string

CC(C)(C)CC(C)(C)c1ccc(OCCOCCOCCOCCOCCOCCOCCO)cc1

InChI

1S/C28H50O8/c1-27(2,3)24-28(4,5)25-6-8-26(9-7-25)36-23-22-35-21-20-34-19-18-33-17-16-32-15-14-31-13-12-30-11-10-29/h6-9,29H,10-24H2,1-5H3

InChI key

HNLXNOZHXNSSPN-UHFFFAOYSA-N

General description

Triton™ X-114 is a nonionic detergent. It is a good detergent for solubilizing membranes having reversible phase-separation property useful for the separation of intrinsic membrane proteins. Solution of Triton™ X-114 is homogeneous at 0°C but phase separation into aqueous phase and a detergent phase occurs above 20°C. Phase separation of proteins in solutions of Triton™ X-114 has been investigated. This octylphenol ethoxylate is compatible with anionic, cationic, and other nonionic surfactants and chemically stable in most acidic & alkaline solutions.

Application

Triton™ X-114 has been used:
  • To remove endotoxin from solutions of protein using phase separation technique
  • In the extraction and purification of DNA from endotoxin
  • In the biphasic extraction of lipoproteins from bacterial cell wall
  • As a non-ionic detergent with a low cloud point (23 °C) enabling protein solubilization with phase-partitioning of hydrophilic from amphiphilic proteins

Legal Information

Triton is a trademark of The Dow Chemical Company or an affiliated company of Dow

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signalword

Danger

Storage Class

10 - Combustible liquids

flash_point_f

483.8 °F - closed cup

flash_point_c

251 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB3627
MKDB3625
MKCZ7242
MKCZ6005
MKCX0957

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Articles

Glycosylphosphatidylinisotol-anchored Glycoproteins Overview

Glycosylphosphatidylinisotol- (GPI) anchored proteins have been identified throughout a broad range of eukaryotic species ranging from humans to insects, yeasts, bacteria, and fungi, suggesting that they are an ancient modification.

糖基化磷脂酰肌醇锚定糖蛋白概述

GPI锚定糖蛋白

Nozomu Takahashi et al.
FEBS open bio, 7(9), 1338-1349 (2017-09-15)
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Golenbock D T, et al.
Cellular Immunology, 258(1), 29-37 (2009)
Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Gehring A J, et al.
Journal of Immunology, 173(4), 2660-2668 (2004)
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Global Trade Item Number

SKUGTIN
X114-5GA04061837603280
X114-1L04061837544699
X114-100ML04061837603228
X114-500ML04061837603266
X114-1GA04061837544675