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Merck
CN

Y0000001

Detomidine hydrochloride

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C12H14N2 · HCl
CAS Number:
Molecular Weight:
222.71
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

pharmaceutical primary standard

API family

dexmedetomidine, medetomidine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Cl-].[nH]1cncc1Cc2c(c(ccc2)C)C.[H+]

InChI

1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H

InChI key

OIWRDXKNDCJZSM-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Detomidine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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E L M Pimenta et al.
Equine veterinary journal, 43(3), 332-340 (2011-04-16)
Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia. Hyoscine would induce positive chronotropism of shorter duration than atropine, without adversely impairing intestinal motility in detomidine sedated horses. Ten minutes after detomidine (0.02 mg/kg bwt, i.v.), physiological
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 38(6), 544-554 (2011-10-13)
To examine the influence of a detomidine constant rate infusion (CRI) on cardiovascular function, isoflurane requirements and recovery quality in horses undergoing elective surgery. Prospective, randomized, blinded, clinical trial. Twenty adult healthy horses. After sedation (detomidine, 10 μg kg(-1) intravenously [IV]) and
Melanie L Church et al.
Veterinary ophthalmology, 15 Suppl 2, 77-83 (2012-04-14)
The main objective was to record electroretinogram (ERG) parameters of normal thoroughbred mares using the HMsERG, a mini-Ganzfeld electroretinographic unit, and a contact lens electrode. The second objective was to determine whether IV detomidine hydrochloride at 0.015 mg/kg is consistently



Global Trade Item Number

SKUGTIN
Y000000104061833801611