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Y0000384

All-rac-alpha-tocopheryl acetate for peak identification

Name: All-rac-alpha-tocopheryl acetate for peak identification
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

DL-α-Tocopherol acetate, Vitamin E acetate, all-rac-α-Tocopheryl acetate

Empirical Formula (Hill Notation):

C₃₁H₅₂O₃

CAS Number:

7695-91-2

Molecular Weight:

472.74

Beilstein:

97512

MDL number:

MFCD00072042

PubChem Substance ID:

329830929

NACRES:

NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

API family

tocopherol

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

density

0.96 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Analytical Reference Standards

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Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
All-rac-alpha-tocopheryl acetate, the ester of all-rac-alpha-tocopherol, is a commercial form of vitamin E. It is responsible for the protection of phenol groups of the parent tocopherol against oxidation.

Application

All-rac-alpha-tocopheryl acetate for peak identification may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

No data available

Flash Point(C)

No data available

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Succinic Acids?Advances in Research and Application: 2013 Edition: ScholarlyBrief

Acton QA

Succinic Acids?Advances in Research and Application (2013)

All-rac-alpha-tocopherol acetate is a better vitamin E source than all-rac-alpha-tocopherol succinate for broilers

Jensen S, et al.

The Journal of Nutrition, 129(7), 1355-1360 (1999)

all-rac-?-Tocopheryl acetate

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 129(7), 3802-3804 (2011)

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.

Po-Hsien Huang et al.

Science signaling, 6(267), ra19-ra19 (2013-03-21)

Vitamin E is a fat-soluble vitamin with antioxidant properties. Tocopherols are the predominant form of vitamin E found in the diet and in supplements and have garnered interest for their potential cancer therapeutic and preventive effects, such as the dephosphorylation

New strategy of α- and γ-tocopherol to prevent contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures.

Adis Tasanarong et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 28(2), 337-344 (2013-01-15)

Contrast-induced acute kidney injury (CI- AKI) increases the likelihood of patient morbidity and mortality following coronary procedures. Volume supplement with saline is the standard treatment to prevent CI-AKI. Additional antioxidant prophylaxis has often yielded conflicting results. The present study was

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