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About This Item
Empirical Formula (Hill Notation):
C16H17ClN2S
CAS Number:
Molecular Weight:
304.84
UNSPSC Code:
41116107
NACRES:
NA.24
SMILES string
S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCCNC
InChI
1S/C16H17ClN2S/c1-18-9-4-10-19-13-5-2-3-6-15(13)20-16-8-7-12(17)11-14(16)19/h2-3,5-8,11,18H,4,9-10H2,1H3
InChI key
YHFXGBOUSIKGMZ-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
chlorpromazine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Chlorpromazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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R Ninci et al.
Journal of chromatography, 381(2), 315-322 (1986-09-05)
A gas chromatographic method using nitrogen-selective detection for the quantitative determination of nanogram amounts of chlorimipramine, chlorpromazine and their nor1 and nor2 derivatives in plasma is described. Derivatization with trifluoroacetic anhydride of nor1 and nor2 metabolites allowed the chromatographic separation
G P Sgaragli et al.
Bollettino della Societa italiana di biologia sperimentale, 60(9), 1757-1763 (1984-09-30)
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with
D L Newton et al.
Biochemistry, 28(9), 3750-3757 (1989-05-02)
In the presence of Ca2+ norchlorpromazine isothiocyanate forms a monocovalent complex with calmodulin: CAPP1-calmodulin (Newton et al, 1983). Trypsin digestion of [3H]CAPP1-calmodulin yields as the major radioactive peptide N epsilon-CAPP-Lys-Met-Lys, corresponding to residues 75-77 of calmodulin. Stoichiometric amounts of all
J L Borowitz et al.
Research communications in chemical pathology and pharmacology, 48(2), 305-308 (1985-05-01)
Although no differences in membrane stabilization by calcium were noted between leukemic (P-388) and normal murine leukocytes, tumor cells were shown to be more resistant to damage by ethanol but not by desmethylchlorpromazine. Furthermore, verapamil protected tumor cells but not
G P Sgaragli et al.
Bollettino della Societa italiana di biologia sperimentale, 60(9), 1727-1733 (1984-09-30)
Data obtained in this preliminary study show that in patients chronically treated either with Chlorimipramine (n = 6) or with Chlorpromazine (n = 2), significant amounts of the corresponding Nor1- and Nor2-metabolites were detected in plasma. The role of these
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