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Merck
CN

Y0000553

Doxazosin mesilate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Doxazosin mesylate, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate, Doxazosin methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C23H25N5O5 · CH3SO3H
CAS Number:
77883-43-3
Molecular Weight:
547.58
NACRES:
NA.24
PubChem Substance ID:
329831016
UNSPSC Code:
41116107
MDL number:
MFCD00216023

Key Documents

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Product Name

Doxazosin mesilate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

SMILES string

CS(O)(=O)=O.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4

InChI key

VJECBOKJABCYMF-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

doxazosin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Related Categories

Application

Doxazosin mesilate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

α1-adrenoceptor antagonist; relaxes smooth muscles of the prostate

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Tanju Keten et al.
Urology, 85(1), 189-194 (2014-12-23)
To compare the efficacy of 4 mg and 8 mg doxazosin XL treatments in patients with benign prostatic hyperplasia-related lower urinary tract symptoms and determine the efficiency of 8 mg in those patients with inadequate response to 4 mg. A

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