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Y0000802

Dipyridamole for peak identification

Name: Dipyridamole for peak identification
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

Dipyridamole

Empirical Formula (Hill Notation):

C₂₄H₄₀N₈O₄

CAS Number:

58-32-2

Molecular Weight:

504.63

MDL number:

MFCD00010555

PubChem Substance ID:

329831157

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

dipyridamole

manufacturer/tradename

EDQM

mp

165-166 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO

InChI

1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChI key

IZEKFCXSFNUWAM-UHFFFAOYSA-N

Gene Information

human ... PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030)

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dipyridamole for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

D2850000

Dipyridamole, European Pharmacopoeia (EP) Reference Standard

1220506

Dipyridamole, United States Pharmacopeia (USP) Reference Standard

1220517

1220561

1220528

1220539

1220540

1220559

BP131

Dipyridamole, British Pharmacopoeia (BP) Reference Standard

BP1102

Dipyridamole impurity standard, British Pharmacopoeia (BP) Reference Standard

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Dipyridamole for preventing stroke and other vascular events in patients with vascular disease.

E L L M De Schryver et al.

The Cochrane database of systematic reviews, (2)(2), CD001820-CD001820 (2006-04-21)

Patients with limited cerebral ischaemia of arterial origin are at risk of serious vascular events (4% to 11% annually). Aspirin reduces that risk by 13%. In one trial, adding dipyridamole to aspirin was associated with a 22% risk-reduction compared with

Translational therapeutics of dipyridamole.

Hyung-Hwan Kim et al.

Arteriosclerosis, thrombosis, and vascular biology, 28(3), s39-s42 (2008-01-05)

Dipyridamole (DP) is a phosphodiesterase inhibitor that increases the intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanine monophosphate (cGMP) by preventing their conversion to AMP and GMP, respectively. By increasing cAMP and cGMP levels in platelets, DP reversibly

The value of stress perfusion cardiovascular magnetic resonance imaging for patients referred from the adult congenital heart disease clinic: 5-year experience at the Toronto General Hospital.

Djeven P Deva et al.

Cardiology in the young, 24(5), 822-830 (2013-09-21)

Vasodilator stress perfusion cardiovascular magnetic resonance imaging is a clinically useful tool for detection of clinically significant myocardial ischaemia in adults. We report our 5-year retrospective experience with perfusion cardiovascular magnetic resonance in a large, quarternary adult congenital heart disease

Safety of fixed-dose aspirin-extended-release dipyridamole in patients with ischemic heart disease.

Natalie Crown et al.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(9), 728-733 (2010-04-23)

The safety of fixed-dose combination aspirin-extended-release (ER) dipyridamole for stroke prevention in patients with ischemic heart disease is reviewed. Randomized controlled trials have established the superiority of aspirinER dipyridamole over aspirin alone for secondary stroke prevention. One limitation of this

Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.

Christopher B Pattillo et al.

Annals of the New York Academy of Sciences, 1207, 83-88 (2010-10-20)

Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular

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