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Merck
CN

Y0000806

Arbutin

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Hydroxyphenyl-β-D-glucopyranoside, p-Arbutin, Hydroquinone β-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):
C12H16O7
CAS Number:
Molecular Weight:
272.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
89673
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InChI key

BJRNKVDFDLYUGJ-RMPHRYRLSA-N

SMILES string

OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1

grade

pharmaceutical primary standard

API family

arbutin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Arbutin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Certificates of Analysis (COA)

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Elena S Chernetsova et al.
Rapid communications in mass spectrometry : RCM, 26(11), 1329-1337 (2012-05-05)
Bergenia crassifolia is a plant widely used in herbal medicine. Its chemical composition has been little studied, and no studies using high-resolution mass spectrometry (HRMS) have been performed. Its phenolic components are of particular interest, due to the interest in
Manal Mohamed Elhassan Taha et al.
Journal of ethnopharmacology, 141(1), 273-281 (2012-03-01)
Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. The current study is an attempt to evaluate the anti-ulcerogenic activities of arbutin, a major constituent of Turnera diffusa on two ulcer
Yukiko Yamashita-Higuchi et al.
Chemical & pharmaceutical bulletin, 60(10), 1347-1350 (2012-10-06)
From the leaves of Grevillea robusta, compounds whose NMR data were superimposable on those of robustasides B and C were isolated along with two new compounds, (E)-2,5-dihydroxycinnamic acid esters of arbutin and D-glucose, and two known compounds, robustaside A and
Dong-Ho Seo et al.
Applied microbiology and biotechnology, 95(6), 1417-1425 (2012-07-31)
Arbutins (α- and β-arbutins) are glycosylated hydroquinones that are commercially used in the cosmetic industry. These compounds have an inhibitory function against tyrosinase, a critical enzyme for generating pigments, which leads to the prevention of melanin formation, resulting in a
Tilak Khanal et al.
Biochemical and biophysical research communications, 413(2), 318-324 (2011-09-06)
A possible role for metabolism by the human intestinal microflora in arbutin-induced cytotoxicity was investigated using human hepatoma HepG2 cells. When the cytotoxic effects of arbutin and hydroquinone (HQ), a deglycosylated metabolite of arbutin, were compared, HQ was more toxic

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