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Y0001323

Aristolochia

Name: Aristolochia
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Aristolochic acid I, TR 1736

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₁NO₇

CAS Number:

313-67-7

Molecular Weight:

341.27

NACRES:

NA.24

PubChem Substance ID:

329831366

UNSPSC Code:

41116107

MDL number:

MFCD00004996

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Properties

grade

pharmaceutical primary standard

API family

aristolochia

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O

InChI

1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

InChI key

BBFQZRXNYIEMAW-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aristolochia EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Potent phospholipase A₂ inhibitor, including calcium ionophore-induced phospholipase A₂ activity in neutrophils. Kidney tumor initiator in experimental animal model.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H340,H350

pcodes

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on bibliographic sources.

Michael Heinrich et al.

Journal of ethnopharmacology, 125(1), 108-144 (2009-06-10)

More than 100 cases of nephropathy over the last 10 years caused by the systemic and longer term application of Chinese snakeroot (Aristolochia fangchi) highlighted the risk of using preparations which contain aristolochic acids. On the other hand anecdotal evidence

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy.

Heinz H Schmeiser et al.

International journal of cancer, 135(2), 502-507 (2014-06-13)

Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination with Aristolochia clematitis seeds. Both nephropathies have a

A Balkan riddle's serendipitous solution.

Jon Cohen

Science (New York, N.Y.), 344(6180), 146-146 (2014-04-12)

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Global Trade Item Number

SKU	GTIN
Y0001323	04061833807217