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Merck
CN

Y0001489

2-(Dimethylamino)ethyl methacrylate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Methacrylic acid 2-(dimethylamino)ethyl ester

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About This Item

Linear Formula:
CH2=C(CH3)COOCH2CH2N(CH3)2
CAS Number:
2867-47-2
Molecular Weight:
157.21
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329831453
EC Number:
220-688-8
Beilstein/REAXYS Number:
1757048
MDL number:
MFCD00008589

Key Documents

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Product Name

2-(Dimethylamino)ethyl methacrylate, European Pharmacopoeia (EP) Reference Standard

format

neat

InChI key

JKNCOURZONDCGV-UHFFFAOYSA-N

InChI

1S/C8H15NO2/c1-7(2)8(10)11-6-5-9(3)4/h1,5-6H2,2-4H3

SMILES string

CN(C)CCOC(=O)C(C)=C

grade

pharmaceutical primary standard

vapor density

5.4 (vs air)

vapor pressure

<1 mmHg ( 25 °C)

API family

amino methacrylate copolymer, basic butylated methacrylate copolymer, copolymers

manufacturer/tradename

EDQM

refractive index

n20/D 1.439 (lit.)

bp

182-192 °C (lit.)

density

0.933 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

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Related Categories

Application

2-(Dimethylamino)ethyl methacrylate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

147.2 °F - closed cup

flash_point_c

64 °C - closed cup

Regulatory Information

危险化学品
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Tomohiro Kamada et al.
Colloids and surfaces. B, Biointerfaces, 123, 878-886 (2014-12-04)
Brushes of a polymer, namely poly(carboxymethylbetaine) (PCMB), were fabricated on silicon wafers by reversible addition-fragmentation chain-transfer (RAFT) polymerization using a surface-confined RAFT agent having an aromatic group at its bottom. The polymer brush showed effective suppression of the non-specific adsorption
Íris Duarte et al.
Pharmaceutical research, 32(1), 222-237 (2014-08-20)
To present a new screening methodology intended to be used in the early development of spray-dried amorphous solid dispersions. A model that combines thermodynamic, kinetic and manufacturing considerations was implemented to obtain estimates of the miscibility and phase behavior of
Makoto Ishida et al.
Drug development and industrial pharmacy, 40(8), 1054-1064 (2013-06-21)
Abstract The applicability of porous spherical silica (PSS) was evaluated as core particles for pharmaceutical products by comparing it with commercial core particles such as mannitol (NP-108), sucrose and microcrystalline cellulose spheres. We investigated the physical properties of core particles
Chia-Wen Lo et al.
PloS one, 9(5), e97627-e97627 (2014-05-16)
Ultrasound (US) has been found to facilitate the transport of DNA across cell membranes. However, the transfection efficiency is generally low, and the expression duration of the transfected gene is brief. In this study, a tertiary polycation, Poly(2-(dimethylamino) ethyl methacrylate)
Kateřina Punčochová et al.
International journal of pharmaceutics, 469(1), 159-167 (2014-04-23)
The objective of this study was to investigate the effect of different polymeric carriers in solid dispersions with an active pharmaceutical ingredient (API) on their water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate
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