Key Documents

View All Documentation

Z2376

Zinquin

Name: Zinquin
Brand: SIAL

≥95% (HPLC), solid

Synonym(s):

2-[[2-Methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]acetic acid, Zinquin A

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₈N₂O₅S

CAS Number:

151606-29-0

Molecular Weight:

386.42

NACRES:

NA.21

PubChem Substance ID:

329831606

UNSPSC Code:

12352100

MDL number:

MFCD03452711

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Quality Level

100

assay

≥95% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble, methanol: soluble

functional group

carboxylic acid

storage temp.

2-8°C

SMILES string

Cc1ccc(cc1)S(=O)(=O)Nc2cc(OCC(O)=O)cc3ccc(C)nc23

InChI

1S/C19H18N2O5S/c1-12-3-7-16(8-4-12)27(24,25)21-17-10-15(26-11-18(22)23)9-14-6-5-13(2)20-19(14)17/h3-10,21H,11H2,1-2H3,(H,22,23)

InChI key

CGNKOBNGEFZRQU-UHFFFAOYSA-N

Related Categories

Analytical Reagents

Chromatography & Spectroscopy Reagents

Indicators

Application

Zinquin has been used to detect intracellular zinc.

Biochem/physiol Actions

Zinquin is a membrane-permeant fluorophore. It is used to detect zinc in cells by UV fluorescence. Zinquin ethyl ester can be used to monitor the change in intracellular concentrations of Zn²⁺ in thymocytes and hepatocytes. The ester is excited at 368nm and emits at 490nm.

Other Notes

Free acid or salt as available

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Zinc signals promote IL-2-dependent proliferation of T cells.

Jennifer Kaltenberg et al.

European journal of immunology, 40(5), 1496-1503 (2010-03-05)

Zinc signals, i.e. a change of the intracellular concentration of free zinc ions in response to receptor stimulation, are involved in signal transduction in several immune cells. Here, the role of zinc signals in T-cell activation by IL-2 was investigated

Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation.

Ai Q Truong-Tran et al.

Biochemical pharmacology, 66(8), 1459-1468 (2003-10-14)

The epithelium lining the airways is a physical barrier as well as a regulator of physiological and pathological events in the respiratory system. Damage to the epithelium by oxidants released from inflammatory cells is a critical factor in the pathogenesis

Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells.

Kilari Sreenivasulu et al.

Journal of food science, 75(4), H123-H128 (2010-06-16)

The effect of red wine (RW), red grape juice (RGJ), green tea (GT), and representative polyphenols on Caco-2 cell (65)Zn uptake was explored. RW, RGJ, and GT enhanced the uptake of zinc from rice matrix. Fractionation of RW revealed that

The supplementation of zinc increased the apoptosis of airway smooth muscle cells by increasing p38 phosphorylation.

Chiou Y L.

Environmental Toxicology and Pharmacology, 33(1), 70-77 (2012)

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.

Kapetanovic R, et al.

Faseb Journal, 30(5), 1901-1912 (2016)

View All Related Papers

Global Trade Item Number

SKU	GTIN
Z2376-5MG	04061832753348

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service