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01148

Sigma-Aldrich

Sodium fluoride

puriss., 98.5-100.5% (calc. to the dried substance), meets analytical specification of Ph. Eur., BP, USP

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Linear Formula:
NaF
CAS Number:
7681-49-4
Molecular Weight:
41.99
EC Number:
231-667-8
MDL number:
MFCD00003524
eCl@ss:
38050104
PubChem Substance ID:
329747226
NACRES:
NA.21

vapor pressure

1.4 mmHg ( 0 °C)

Quality Level

200

grade

puriss.

Assay

98.5-100.5% (calc. to the dried substance)

form

powder

quality

meets analytical specification of Ph. Eur., BP, USP

impurities

acidity or alkalinity, complies
 organic volatile impurities, complies (GC)
 residual solvents, complies
≤0.002% heavy metals (as Pb)
≤0.1% free alkali (as NaOH)
≤0.2% free acid (as HF)
≤0.2% sodium hexafluorosilicate (Na2SiF6)

loss

≤0.5% loss on drying, 150 °C

mp

993 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Fe: ≤50 mg/kg

suitability

complies for appearance of solution

SMILES string

[F-].[Na+]

InChI

1S/FH.Na/h1H;/q;+1/p-1

InChI key

PUZPDOWCWNUUKD-UHFFFAOYSA-M

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General description

Sodium fluoride (NaF) is a metallic halide. It has been reported as dental caries preventive agent. It is the most widely employed preservative for glucose in blood. It has been reported to stabilize hepatic microsomal glucose-6-P phosphohydrolase enzyme.

Application

Sodium fluoride may be employed as fluorination agent in the synthesis of aromatic and aliphatic fluorides, via metathesis. It may be used to prepare the lysis buffer.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 - H315 - H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

Supplementary Hazards

EUH032

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品

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J G Drachman et al.
The Journal of biological chemistry, 270(10), 4979-4982 (1995-03-10)
c-Mpl is a member of the cytokine receptor superfamily, expressed primarily on hematopoietic cells. Recently, the c-Mpl ligand was cloned and found to have thrombopoietic activity. In this paper we report that ligand binding induced tyrosine phosphorylation in BaF3 cells
Effectiveness of sodium fluoride as a preservative of glucose in blood.
Chan AY, et al.
Clinical Chemistry, 35(2), 315-317 (1989)
Synthesis of fluorides by metathesis with sodium fluoride.
Tullock CW and Coffman DD.
The Journal of Organic Chemistry, 25(11), 2016-2019 (1960)
A J Lange et al.
The Journal of biological chemistry, 261(1), 101-107 (1986-01-05)
Stabilization and inhibition of hepatic microsomal glucose-6-P phosphohydrolase (EC 3.1.3.9) by F- requires the presence of Al3+ ions. At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of
Hye-Jin Lee et al.
The Kaohsiung journal of medical sciences, 31(6), 303-308 (2015-06-05)
Dental caries preventive agents, such as sodium fluoride (NaF) and bamboo salt (BS), are known to cause cellular growth that is characterized by morphological and gene expression changes. This study was designed to investigate the dual effect of NaF and
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