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Merck
CN

13433

Sigma-Aldrich

Sodium bicarbonate

puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

Synonym(s):

Sodium hydrogen carbonate

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About This Item

Linear Formula:
NaHCO3
CAS Number:
144-55-8
Molecular Weight:
84.01
Beilstein:
4153970
EC Number:
205-633-8
MDL number:
MFCD00003528
UNSPSC Code:
12352302
eCl@ss:
38020213
PubChem Substance ID:
329750171
NACRES:
NA.21
Assay:
99.0-100.5%
Form:
powder

Key Documents

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grade

puriss.

Quality Level

200

Assay

99.0-100.5%

form

powder

quality

meets analytical specification of Ph. Eur., BP, USP, FCC, E500

impurities

ammonia (NH3), in accordance
 organic volatile impurities, complies
 residual solvents, complies
 water-insoluble matter, complies
≤0.002% ammonium (NH4), complies

loss

≤0.2% loss on drying (silica gel)

pH

≤8.6 (20 °C, 5%)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

density

2.16 g/mL at 25 °C (lit.)

anion traces

carbonate (CO32-): in accordance
chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤0.5 mg/kg
As: ≤2 mg/kg
Ca: ≤100 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
K: ≤100 mg/kg
Pb: ≤2 mg/kg

suitability

complies for appearance of solution

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

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Application

Sodium bicarbonate may be involved in the fabrication of silica based monolith columns which can be used in capillary electrochromatography. It can also be used to maintain the pH of the column for the separation of proteins via ion exchange displacement chromatography.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ1503
MKCX8760
MKCX8206
MKCX6007
MKCX5948

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Silica-based monoliths for capillary electrochromatography: Methods of fabrication and their applications in analytical separations
Allen D and Rassi EZ
Electrophoresis, 24, 3962-3976 (2003)
Use of the sodium salt of poly (vinylsulfonic acid) as a low-molecular-weight displacer for protein separations by ion-exchange displacement chromatography
Jen D.C.S and Pinto.GN
Journal of Chromatography A, 519(1), 87-98 (1990)
Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute
Joshua C Tremblay et al.
The Journal of physiology, 593(3), 723-737 (2014-11-25)
Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased by acute hypoxia during rest by unknown mechanisms. Oral administration of acetazolamide blunts the pulmonary vascular pressure response to acute hypoxia, thus permitting the observation of IPAVA blood flow with minimal
Roberto J Diaz et al.
American journal of physiology. Cell physiology, 306(12), C1191-C1199 (2014-04-25)
We have previously shown that ischemic preconditioning (IPC) protection against necrosis in whole hearts and in both fresh and cultured cardiomyocytes, as well as the improved regulatory volume decrease to hypoosmotic swelling in cardiomyocytes, is abrogated through Cl(-) channel blockade
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