Skip to Content
Merck
CN
All Photos(3)

Key Documents

View All Documentation

360481

Sigma-Aldrich

1,4-Dioxane

ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer

Synonym(s):

Diethylene oxide, Dioxane

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
123-91-1
Molecular Weight:
88.11
Beilstein:
102551
EC Number:
204-661-8
MDL number:
MFCD00006571
UNSPSC Code:
12352005
PubChem Substance ID:
329755260
NACRES:
NA.21
grade:
ACS reagent
bp:
100-102 °C (lit.)
vapor pressure:
27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

grade

ACS reagent

Quality Level

200

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Assay

≥99.0%

form

liquid

autoignition temp.

356 °F

contains

≤25 ppm BHT as stabilizer

expl. lim.

22 %

dilution

(for analytical testing)

impurities

≤0.0016 meq/g Titr. acid
≤0.005% Peroxide (as H2O2)
≤0.01% Carbonyl (as HCHO)
≤0.05% water

evapn. residue

≤0.005%

color

APHA: ≤20

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

transition temp

freezing point ≥11.0

density

1.034 g/mL at 25 °C (lit.)

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

1,4-Dioxane is a heterocyclic organic compound that is commonly used as a solvent in several chemical reactions. It is also used as a stabilizer in chlorinated solvents.
Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

Application

1,4-Dioxane can be used as:      
  • A solvent in the N-methylation of amines by reductive functionalization of CO2 in the presence of NaBH4 as the reducing reagent.      
  • An additive to synthesize 3-hydroxylisoindolin-1-ones via hydroxylhydrative aza-cyclization of 2-alkynylbenzamide.

A mixture of 1,4-dioxane/ethanol/formic acid solvent system can be used in the depolymerization of lignin to synthesize value-added phenolic monomers.

Signal Word

Danger

Hazard Statements

H225,H319,H335,H350

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019,EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SHBS6693
SHBS4010
SHBS2387
SHBR7675
SHBS3123

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service