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Merck
CN

571261

Piperidine

biotech. grade, ≥99.5%

Synonym(s):

Hexahydropyridine

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About This Item

Empirical Formula (Hill Notation):
C5H11N
CAS Number:
110-89-4
Molecular Weight:
85.15
UNSPSC Code:
12352005
NACRES:
NA.21
PubChem Substance ID:
329758271
EC Number:
203-813-0
Beilstein/REAXYS Number:
102438
MDL number:
MFCD00005979
Grade:
biotech. grade
Assay:
≥99.5%
Technique(s):
DNA sequencing: suitable
Bp:
106 °C (lit.)
106 °C
Vapor pressure:
23 mmHg ( 20 °C)

Key Documents

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Product Name

Piperidine, biotech. grade, ≥99.5%

form

liquid

InChI key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

SMILES string

C1CCNCC1

grade

biotech. grade

vapor density

3 (vs air)

vapor pressure

23 mmHg ( 20 °C)

assay

≥99.5%

technique(s)

DNA sequencing: suitable

impurities

<0.3% water

refractive index

n20/D 1.452 (lit.)

bp

106 °C (lit.)
106 °C

mp

−13 °C (lit.)

solubility

organic solvents: soluble(lit.)
water: miscible(lit.)

density

0.862 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 290 Amax: <1.000
λ: 370 Amax: <0.050

Quality Level

100

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Application

Fits Applied Biosystems 431 and 433A peptide synthesizers.
Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

General description

Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

60.8 °F - closed cup

flash_point_c

16 °C - closed cup

Regulatory Information

易制毒化学品（2类）
危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SHBM2720
SHBH5650V
SHBH5309V
BCBH1918V
1450489V

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W B Mattes et al.
Biochimica et biophysica acta, 868(1), 71-76 (1986-10-16)
The volatile, secondary amine piperidine is used in the Maxam-Gilbert chemical method of DNA sequencing to create strand breaks in DNA at sites of damaged bases. As such it is often used in generalized studies of DNA damage to identify
Peptide Synthesis.
Miao Z and Cheng Z
Bio-protocol, 2(14) (2012)
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so
Marek Łuczkowski et al.
Inorganic chemistry, 47(23), 10875-10888 (2008-10-31)
A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins.Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)4G-NH2) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective
Xuwang Chen et al.
Bioorganic & medicinal chemistry, 20(12), 3856-3864 (2012-05-18)
A novel series of piperidine-linked amino-triazine derivatives were designed, synthesized and evaluated for in vitro anti-HIV activity as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. Screening results indicated that most compounds showed excellent activity against wild-type
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