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650463

Sigma-Aldrich

Dichloromethane

HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains 50-150 ppm amylene as stabilizer

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Synonym(s):
methylene chloride, Methylene chloride
Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
75-09-2
Molecular Weight:
84.93
Beilstein:
1730800
EC Number:
200-838-9
MDL number:
MFCD00000881
PubChem Substance ID:
329760022
NACRES:
NA.04

grade

HPLC Plus
for residue analysis

Quality Level

100

vapor density

2.9 (vs air)

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

Assay

≥99.9%

form

liquid

autoignition temp.

1223 °F

contains

50-150 ppm amylene as stabilizer

expl. lim.

22 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤ 1.0 ppb Fluorescence (quinine) at 365 nm
≤0.01% water

evapn. residue

≤0.0001%

halogenated residue

≤10 ng/L (as heptachlor epoxide)

refractive index

n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

λ

H2O reference

UV absorption

λ: 235 nm Amax: 1.0
λ: 240 nm Amax: 0.10
λ: 250 nm Amax: 0.02
λ: 300-400 nm Amax: 0.005

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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General description

Dichloromethane is a polar and highly volatile organic compound (VOC), known for its versatile use in industries as an extraction solvent and metal cleaner and consumer products such as adhesives, spray shoe polishes, paint, and adhesive removers.

Application

Dichloromethane may be used in the following:

  • Extraction of neonicotinoids from honey samples along with acetonitrile using dispersive liquid-liquid microextraction (DLLME)
  • Ultrasonic solvent extraction and clean-up of roasted coffee samples for the analysis of 7 pesticide residues by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
  • DLLME based additional pre-concentration of the sample extracts in the analysis of three amphenicols in food products of animal origin by HPLC with UV detection
  • Removal of organic phase of the obtained soil sample extracts in the determination of two sulfonylurea herbicides using HPLC
  • Testing of four extraction solvents in the development of a HPLC-amperometric detection based method for the analysis of three carbamate residues in liquid and solid food samples
  • Extraction of metrafenone from vegetable samples by matrix solid-phase dispersion (MSPD method followed by HPLC analysis

Suitable for HPLC, spectrophotometry, environmental testing

Packaging

View returnable container options.

Other Notes

Pesticide Residue Analysis (as Heptachlor Epoxide) <10 ng/L
Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Warning

Hazard Statements

H315 - H319 - H336 - H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

危险化学品

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Jane A Mullaney et al.
Journal of agricultural and food chemistry, 61(12), 3039-3046 (2013-03-07)
Glucosinolates from the genus Brassica can be converted into bioactive compounds known to induce phase II enzymes, which may decrease the risk of cancers. Conversion via hydrolysis is usually by the brassica enzyme myrosinase, which can be inactivated by cooking
Rodney C Baker et al.
Methods in enzymology, 538, 89-105 (2014-02-18)
Mass spectrometry technology has enabled significant advances in detailing the alterations of the lipidome in response to pathological conditions or experimental manipulations. Lipids comprise a wide range of compounds with functions that include structural, intracellular signaling, trafficking, and storage. Characterization
Daniela Giustarini et al.
Nature protocols, 8(9), 1660-1669 (2013-08-10)
This protocol describes a procedure for determining glutathione (GSH) and glutathione disulfide (GSSG) concentrations in blood and other tissues. Artifactual oxidation to GSSG of 5-15% of the GSH found in a sample can occur during deproteination of biological samples with
Biodegradation of dichloromethane in an estuarine environment.
Krausova VI, et al.
Hydrobiologia, 559(1), 77-83 (2006)
Vibrational Relaxation in Liquid Dichloromethane.
Hunter JL and Dardy HD.
J. Chem. Phys. , 42(8), 2961-2966 (1965)
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