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91707

Trifluoroacetic acid

Name: Trifluoroacetic acid
Brand: SIGALD

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Synonym(s):

TFA

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About This Item

Linear Formula:

CF₃COOH

CAS Number:

76-05-1

Molecular Weight:

114.02

UNSPSC Code:

12352106

NACRES:

NA.21

PubChem Substance ID:

329770068

EC Number:

200-929-3

Beilstein/REAXYS Number:

742035

MDL number:

MFCD00004169

Assay:

≥99.0% (GC)

Form:

liquid

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Properties

vapor density

3.9 (vs air)

Quality Level

200

vapor pressure

97.5 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.0% (GC)

form

liquid

technique(s)

HPLC: suitable, LC/MS: suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

pH

1 (20 °C, 1 g/L)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

water: soluble

density

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H₂O reference

UV absorption

λ: 260 nm A_max: 0.9, λ: 270 nm A_max: 0.1, λ: 280 nm A_max: 0.08, λ: 290 nm A_max: 0.07, λ: 300 nm A_max: 0.06, λ: 320 nm A_max: 0.05

suitability

corresponds to standard for RP gradient test

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Application

Trifluoroacetic acid (TFA) may be used in the following studies:

Preparation of TFA reagent for the estimation of serum vitamin A.
To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
Preparation of artemisinin under optimized reaction conditions.

Packaging

package with 10x1mL

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pictograms

GHS05,GHS07

signalword

Danger

hcodes

H314,H332,H412

pcodes

P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

Regulatory Information

危险化学品

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Continuous-flow synthesis of the anti-malaria drug artemisinin.

François Lévesque et al.

Angewandte Chemie (International ed. in English), 51(7), 1706-1709 (2012-01-18)

Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.

J B Neeld et al.

The Journal of nutrition, 79, 454-462 (1963-04-01)

Effect of eluent on the ionization process in liquid chromatography-mass spectrometry.

Risto Kostiainen et al.

Journal of chromatography. A, 1216(4), 685-699 (2008-09-19)

The most widely used ionization techniques in liquid chromatography-mass spectrometry (LC-MS) are electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). All three provide user friendly coupling of LC to MS. Achieving optimal LC-MS conditions is

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Global Trade Item Number

SKU	GTIN
91707-250ML	04061837765544
91707-1ML	04061837765537
91707-10X1ML	04061837765513