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Merck
CN

03181

D-myo-Inositol 1,2,3,5,6-pentakis-phosphate

≥80% (HPLC)

Synonym(s):

L-myo-Inositol 1,2,3,4,5-pentakis-phosphate

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About This Item

Empirical Formula (Hill Notation):
C6H17O21P5
CAS Number:
26326-85-2
Molecular Weight:
580.06
NACRES:
NA.32
PubChem Substance ID:
329747571
UNSPSC Code:
12352202
MDL number:
MFCD08061883

Key Documents

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InChI

1S/C6H17O21P5/c7-1-2(23-28(8,9)10)4(25-30(14,15)16)6(27-32(20,21)22)5(26-31(17,18)19)3(1)24-29(11,12)13/h1-7H,(H2,8,9,10)(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)(H2,20,21,22)/t1-,2-,3+,4-,5-,6-/m1/s1

SMILES string

O[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O

InChI key

CTPQAXVNYGZUAJ-UOTPTPDRSA-N

assay

≥80% (HPLC)

storage temp.

−20°C

Quality Level

100

General description

Aluminum was shown to increase the activity of multiple inositol polyphosphate phosphatathase(MIPP) in hepatic mammalian cells. This cased a decrease in the MIPP substrate, Ins(1,2,3,5,6)P5.

Biochem/physiol Actions

The metabolite inositol is a precursor of inositides, which have an important impact on diverse areas of cellular regulation.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBV9123
BCBV1415
BCBB8093V
BCBB8093

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N Ali et al.
The Biochemical journal, 305 ( Pt 2), 557-561 (1995-01-15)
There is speculation that some of the toxic effects of Al3+ may originate from it perturbing inositol phosphate/Ca2+ signalling. For example, in permeabilized L1210 mouse lymphoma cells, 10-50 microM Al3+ activated Ins(1,3,4,5)P4-dependent Ca2+ mobilization and Ins(1,3,4,5)P4 3-phosphatase activity [Loomis-Husselbee, Cullen
Christopher J Barker et al.
Methods in molecular biology (Clifton, N.J.), 645, 1-19 (2010-07-21)
Inositides have an important impact on diverse areas of cellular regulation. However, since this area has grown exponentially from the mid 1980s onwards, many workers find themselves relatively new to the field. In this chapter, we establish a broad foundation

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