Key Documents

View All Documentation

04260

N-Ethylmaleimide

Name: <I>N</I>-Ethylmaleimide
Brand: SIGMA

purum p.a., ≥99.0% (HPLC)

Synonym(s):

NEM

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₆H₇NO₂

CAS Number:

128-53-0

Molecular Weight:

125.13

NACRES:

NA.26

PubChem Substance ID:

329747901

UNSPSC Code:

12352209

EC Number:

204-892-4

MDL number:

MFCD00005509

Beilstein/REAXYS Number:

112448

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

grade

purum p.a.

Quality Level

200

assay

≥99.0% (HPLC)

ign. residue

≤0.05%

bp

210 °C (lit.)

mp

43-46 °C

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤100 mg/kg

cation traces

Ca: ≤50 mg/kg, Cd: ≤50 mg/kg, Co: ≤50 mg/kg, Cu: ≤50 mg/kg, Fe: ≤50 mg/kg, K: ≤100 mg/kg, Na: ≤100 mg/kg, Ni: ≤50 mg/kg, Pb: ≤50 mg/kg, Zn: ≤50 mg/kg

storage temp.

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

Gene Information

human ... SLC6A3(6531), SLC6A4(6532)

Looking for similar products? Visit Product Comparison Guide

Application

N-Ethylmaleimide has been used to measure low molecular weight thiols bound to plasma proteins.

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H300,H311,H314,H317

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

163.2 °F - closed cup

flash_point_c

72.9 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

pcodes

P260 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Plasma protein thiolation index (PTI) as a biomarker of thiol-specific oxidative stress in haemodialyzed patients.

Colombo G, et al.

Free Radical Biology & Medicine, 89, 443-451 (2015)

Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

Ryan R Falsey et al.

Nature chemical biology, 2(1), 33-38 (2006-01-13)

The actin cytoskeleton supports diverse cellular processes such as endocytosis, oriented growth, adhesion and migration. The dynamic nature of the cytoskeleton, however, has made it difficult to define the roles of the many accessory molecules that modulate actin organization, especially

Thioredoxin m4 controls photosynthetic alternative electron pathways in Arabidopsis.

Agathe Courteille et al.

Plant physiology, 161(1), 508-520 (2012-11-16)

In addition to the linear electron flow, a cyclic electron flow (CEF) around photosystem I occurs in chloroplasts. In CEF, electrons flow back from the donor site of photosystem I to the plastoquinone pool via two main routes: one that

Nociceptive behavior induced by the endogenous opioid peptides dynorphins in uninjured mice: evidence with intrathecal N-ethylmaleimide inhibiting dynorphin degradation.

Koichi Tan-No et al.

International review of neurobiology, 85, 191-205 (2009-07-18)

Dynorphins, the endogenous opioid peptides derived from prodynorphin may participate not only in the inhibition, but also in facilitation of spinal nociceptive transmission. However, the mechanism of pronociceptive dynorphin actions, and the comparative potential of prodynorphin processing products to induce

Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection.

Tatsuki Kurokawa et al.

Biochimica et biophysica acta, 1838(1 Pt B), 382-387 (2013-10-22)

Hv1 (also named, voltage-sensor only protein, VSOP) lacks an authentic pore domain, and its voltage sensor domain plays both roles in voltage sensing and proton permeation. The activities of a proton channel are intrinsic to protomers of Hv1, while Hv1

View All Related Papers

Global Trade Item Number

SKU	GTIN
93598-100MG	04061833282946
8048120500	04022536386508
8048120100	04022536386492
8048129050	04022536386515
I29204-100G	04061833848777
I29204-1KG	04061833848784
04260-5G-F	04061838629319
04260-25G-F	04061838629302

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service