120R-1
CD20 (SP32) Rabbit Monoclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP32, monoclonal
Application:
IHC (p)
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
SP32, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (120R-14), vial of 0.5 mL concentrate (120R-15), bottle of 1.0 mL predilute (120R-17), vial of 1.0 mL concentrate (120R-16), bottle of 7.0 mL predilute (120R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
General description
Anti-CD20 (pan B-cell) reacts with a membrane antigen that is present in B-cells as this epitope is acquired late in the pre-B-cell stage of maturation and remains on cells throughout most of the differentiation process, although it is lost at the plasma cell stage. This antibody recognizes Reed-Sternberg cells, predominant in classic Hodgkin′s disease, in approximately 20% of cases, and approximately half of lymphoblastic lymphoma/leukemias. Since no staining of histiocytes or plasma cells has been observed and CD20 has rarely been detected in T-cell malignancies, it is a dependable marker of B-cell lymphomas. Anti-CD20 does not cross-react with non-hematopoetic neoplasms.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
CD20 Positive Control Slides, Product No. 120S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
监管及禁止进口产品
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Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2006)
P Korkolopoulou et al.
Histopathology, 24(6), 511-515 (1994-06-01)
Recent evidence indicates that membrane-bound immunoglobulin on B lymphocytes is associated with a molecule which comprises the products of the mb-1 and B29 genes. This molecule is a highly specific marker for B-cells, presumably because of its central functional role
G S Pinkus et al.
The American journal of pathology, 133(2), 211-217 (1988-11-01)
Immunoreactivity for L26, a highly effective pan B cell marker that can be detected in paraffin sections, was evaluated in 72 cases of Hodgkin's disease of various histologic types. In all cases of nodular lymphocyte predominance type of Hodgkin's disease
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 120R-16 | 0841683124030 |
| 120R-14 | 0841683124016 |
| 120R-17 | 0841683124047 |
| 120R-18 | 0841683124054 |
| 120R-15 | 0841683124023 |