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12107C

Fetal Bovine Serum

Name: Fetal Bovine Serum
Brand: SIGMA

USA origin, γ-irradiated by SER-TAIN process, sterile-filtered, suitable for cell culture

Synonym(s):

Fetal Calf Sera, Fetal Calf Serum, GI FBS, GI FCS, GI Fetal Bovine Sera, GI Fetal Bovine Serum, GI Fetal Calf Serum, FBS, FCS, sera, serum

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About This Item

UNSPSC Code:

12352207

NACRES:

NA.71

MDL number:

MFCD00132239

Biological source:

bovine fetus

Origin:

USA origin

Sterility:

sterile-filtered

Shipped in:

dry ice

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biological source

bovine fetus

Quality Level

500

sterility

sterile-filtered

product line

FBS Premier

composition

hemoglobin, ≤20 mg/dL

origin

USA origin

technique(s)

cell culture | mammalian: suitable

impurities

≤10 EU/mL endotoxin

shipped in

dry ice

storage temp.

−20°C

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Related Categories

Bovine Serum Albumin

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Fetal Bovine Serum (FBS)

Molecular Biology & Functional Genomics

Application

FBS provides many non-defined growth promoting and survival enhancing factor to cells in culture.

Preparation Note

Gamma irradiation by SER-TAIN process (25-40kGy).

Analysis Note

Endotoxin and hemoglobin tested

Tested for the presence of bacteria, virus, and mycoplasma
Triple filtered with 0.1 micron membrane under aseptic conditions

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.

Robert C Tuckey et al.

The Journal of steroid biochemistry and molecular biology, 112(4-5), 213-219 (2008-11-13)

Cytochrome P450scc (CYP11A1) metabolizes vitamin D3 to 20-hydroxyvitamin D3 as the major product, with subsequent production of dihydroxy and trihydroxy derivatives. The aim of this study was to determine whether cytochrome P450scc could metabolize 1alpha-hydroxyvitamin D3 and whether products were

An antimetastatic role for decorin in breast cancer.

Silvia Goldoni et al.

The American journal of pathology, 173(3), 844-855 (2008-08-09)

Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition. We investigated the effects of decorin on the growth of ErbB2-overexpressing mammary carcinoma

Alteration of gene expression by alcohol exposure at early neurulation.

Feng C Zhou et al.

BMC genomics, 12, 124-124 (2011-02-23)

We have previously demonstrated that alcohol exposure at early neurulation induces growth retardation, neural tube abnormalities, and alteration of DNA methylation. To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a

Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription.

Nan Jiang et al.

Molecular and cellular biology, 29(13), 3556-3568 (2009-04-22)

Insulator elements play a role in gene regulation that is potentially linked to nuclear organization. Boundary element-associated factors (BEAFs) 32A and 32B associate with hundreds of sites on Drosophila polytene chromosomes. We hybridized DNA isolated by chromatin immunoprecipitation to genome

γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.

Anu Sharma et al.

PloS one, 6(11), e28217-e28217 (2011-12-06)

γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore investigated whether γ-radiation results in increased expression of cancer-testis

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Articles

Frequently Asked Questions About Gamma-Irradiated FBS (Serum) and Other Products for Cell Culture

Find answers to questions (FAQs) about fetal bovine serum (FBS) that is gamma-irradiated by the SER-TAIN™ process. Request a sample of FBS at Sigma-Aldrich.com.

Protocols

Freezing and Thawing FBS and Other Sera

Protect your investment with best practices for storing and thawing FBS and other sera. Sample FBS for validation in your cell culture protocol.

Global Trade Item Number

SKU	GTIN
12107C-500IRR	04061838196835
12107C-500ML	04061838251961
12107C-1L	04065266965346
12107C-100ML	04061838078605
12107C-1000ML	04061838261441

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