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13135

N-Benzoyl-L-tyrosine p-amidobenzoic acid sodium salt

Name: <I>N</I>-Benzoyl-<SC>L</SC>-tyrosine p-amidobenzoic acid sodium salt
Brand: SIGMA

lyophilized, ≥98.0% (sum of enantiomers, HPLC)

Synonym(s):

N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt, Bentiromide

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About This Item

Linear Formula:

C₂₃H₁₉N₂O₅Na

CAS Number:

41748-47-4

Molecular Weight:

444.41

NACRES:

NA.83

PubChem Substance ID:

57647058

UNSPSC Code:

12352204

EC Number:

255-530-7

MDL number:

MFCD00042647

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assay

≥98.0% (sum of enantiomers, HPLC)

form

powder or crystals

optical activity

[α]20/D +45±2°, c = 1% in DMF/H₂O 1:1

quality

lyophilized

mp

~210 °C (dec.)

solubility

water: 0.25 g/5mL, clear to slightly hazy

storage temp.

2-8°C

SMILES string

[Na+].Oc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)Nc3ccc(cc3)C([O-])=O)cc1

InChI

1S/C23H20N2O5.Na/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30;/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30);/q;+1/p-1/t20-;/m0./s1

InChI key

HEJYVLSWQWPKPQ-BDQAORGHSA-M

General description

N-Benzoyl-L-tyrosine p-amidobenzoic acid acts as a substrate for peptide hydrolases present in the human small intestinal mucosa. Its degradation to p-aminobenzoic acid helps to assess the pancreatic and renal functionality.

Other Notes

Hydrolysis of benzol-tyrosyl-p-aminobenzoic acid by a human intestinal microvillar peptidase; Substrate for the assay of chymotrypsin in crude biological materials.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid: acute toxicity and effects of renal function on this test.

C Lang et al.

Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 18(9), 551-555 (1980-09-01)

The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid was performed on 24 healthy test subjects, and its toxicity was examined. Eight patients with restricted renal function and known renal disease were also investigated. The pancreatic function test and the same

Non-pancreatic hydrolysis of N-benzoyl-l-tyrosyl-p-aminobenzoic acid (PABA-peptide) in the human small intestine.

E E Sterchi et al.

Clinical science (London, England : 1979), 62(5), 557-560 (1982-05-01)

1. Hydrolysis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) has been measured in soluble and particulate fractions of human small intestinal mucosa. 2. Both soluble and particulate fractions contained enzymic activity capable of splitting the PABA-peptide. In the particulate fractions this activity increased

P.W. Pemberton et al.

Biochemical Society Transactions, 13, 175-175 (1985)

A method for the assay of chymotrypsin in crude biological materials.

A R Imondi et al.

Analytical biochemistry, 54(1), 199-204 (1973-07-01)

Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

Global Trade Item Number

SKU	GTIN
123579-25G	04061838722447
123579-500G	04061833544389
123579-100G	04061838722430
13135-5G	04061833054307

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