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Merck
CN

13135

Sigma-Aldrich

N-Benzoyl-L-tyrosine p-amidobenzoic acid sodium salt

lyophilized, ≥98.0% (sum of enantiomers, HPLC)

别名:

N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt, Bentiromide

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关于此项目

线性分子式:
C23H19N2O5Na
化学文摘社编号:
41748-47-4
分子量:
444.41
EC 号:
255-530-7
MDL编号:
MFCD00042647
UNSPSC代码:
12352204
PubChem化学物质编号:
57647058
NACRES:
NA.83

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方案

≥98.0% (sum of enantiomers, HPLC)

表单

powder or crystals

旋光性

[α]20/D +45±2°, c = 1% in DMF/H2O 1:1

质量

lyophilized

mp

~210 °C (dec.)

溶解性

water: 0.25 g/5mL, clear to slightly hazy

储存温度

2-8°C

SMILES字符串

[Na+].Oc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)Nc3ccc(cc3)C([O-])=O)cc1

InChI

1S/C23H20N2O5.Na/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30;/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30);/q;+1/p-1/t20-;/m0./s1

InChI key

HEJYVLSWQWPKPQ-BDQAORGHSA-M

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一般描述

N-Benzoyl-L-tyrosine p-amidobenzoic acid acts as a substrate for peptide hydrolases present in the human small intestinal mucosa. Its degradation to p-aminobenzoic acid helps to assess the pancreatic and renal functionality.

其他说明

Hydrolysis of benzol-tyrosyl-p-aminobenzoic acid by a human intestinal microvillar peptidase; Substrate for the assay of chymotrypsin in crude biological materials.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BGBC2180V
1357366V
1357366
1325700
360668/1

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P.W. Pemberton et al.
Biochemical Society Transactions, 13, 175-175 (1985)
E E Sterchi et al.
Clinical science (London, England : 1979), 62(5), 557-560 (1982-05-01)
1. Hydrolysis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) has been measured in soluble and particulate fractions of human small intestinal mucosa. 2. Both soluble and particulate fractions contained enzymic activity capable of splitting the PABA-peptide. In the particulate fractions this activity increased
A method for the assay of chymotrypsin in crude biological materials.
A R Imondi et al.
Analytical biochemistry, 54(1), 199-204 (1973-07-01)
C Lang et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 18(9), 551-555 (1980-09-01)
The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid was performed on 24 healthy test subjects, and its toxicity was examined. Eight patients with restricted renal function and known renal disease were also investigated. The pancreatic function test and the same

商品

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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