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135R-1

CD35 (EP197) Rabbit Monoclonal Primary Antibody

Synonym(s):

C3-binding protein, C3BR, C3b/C4b receptor, C4BR, CD35 antigen, CR1, Complement Receptor 1, Complement component (3b/4b) receptor 1 (Knops blood group), Knops blood group antigen

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP197, monoclonal
Application:
IHC (p)
Citations:
12
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biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP197, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (135R-14), vial of 0.1 mL concentrate Research Use Only (135R-14-RUO), vial of 0.5 mL concentrate (135R-15), vial of 1.0 mL concentrate (135R-16), vial of 1.0 mL concentrate Research Use Only (135R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (135R-17-RUO), vial of 1.0 mL predilute ready-to-use (135R-17), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (135R-18-RUO), vial of 7.0 mL predilute ready-to-use (135R-18)

manufacturer/tradename

Cell Marque®

concentration

0.1-5.0 μg/mL (predilute), 2.5-125 μg/mL (concentrate)

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... CR1(1378)

General description

CD35 (complement receptor 1) is a cell membrane-bound, monomeric glycoprotein found on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Analysis Note

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Other Notes

CD35 Positive Control Slides, Product No. 135S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000532149
0000532149
0000509534
0000509534
0000509477

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Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.
Pileri SA, Grogan TM, Harris NL, et al.
Histopathology, 41(1), 1-29 (2002)
Immunohistochemical recognition of human follicular dendritic cell (FDCs) in routinely processed paraffin section.
Kunihikom, M., et al.
The Journal of Histochemistry and Cytochemistry, 50, 1475-1486 (2002)
Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.
Chang KC, Huang X, Medeiros LJ, et al.
The Journal of Pathology, 201(3), 404-412 (2003)
View All Related Papers

Global Trade Item Number

SKUGTIN
135R-16-RUO04061837569562