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15759

Poloxamer 188

Name: Poloxamer 188
Brand: SIGMA

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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About This Item

CAS Number:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

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Properties

form

solid

Quality Level

200

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH₃OH

pH

5.0-7.5 (100 g/L in H₂O), 6.0-7.5 (25 g/L in H₂O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

Application

Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

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Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles.

Jianan Shen et al.

Biomaterials, 34(5), 1581-1590 (2012-11-14)

The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously

Structural characterization and antimicrobial properties of silver nanoparticles prepared by inverse microemulsion method.

Irshad A Wani et al.

Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)

Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and

Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP.

Wendell J Lu et al.

Lipids, 47(6), 571-580 (2012-02-03)

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low and can be difficult to assay in

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Global Trade Item Number

SKU	GTIN
433047-1G	04061825585222
433047-5G	04061831820287
15759-1KG	04061838743428