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163M-1

CD163 (MRQ-26) Mouse Monoclonal Antibody

Name: CD163 (MRQ-26) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

MRQ-26, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-26, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (163M-14), vial of 0.5 mL concentrate (163M-15), bottle of 1.0 mL predilute (163M-17), vial of 1.0 mL concentrate (163M-16), bottle of 7.0 mL predilute (163M-18)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

isotype

IgG1

control

inflamed tissue

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... CD163(9332)

Related Categories

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

General description

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163labels cells of monocytic-macrophage lineage, with expression in the bone marrow and histiocytic neoplasms.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

CD163 Positive Control Slides, Product No. 163S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.

E Backé et al.

Journal of clinical pathology, 44(11), 936-945 (1991-11-01)

A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and

Expression of CD163 in the liver of patients with viral hepatitis.

Atsushi Hiraoka et al.

Pathology, research and practice, 201(5), 379-384 (2005-07-29)

CD163 is a marker of activated macrophages, and increased levels of soluble CD163 have been detected in sera obtained from patients with hepatitis. The aim of this study was to detect the expression of CD163 in the liver from patients

Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163).

P Högger et al.

Journal of immunology (Baltimore, Md. : 1950), 161(4), 1883-1890 (1998-08-26)

The RM3/1 Ag is a membrane glycoprotein restricted to human monocytes and macrophages that evolve in the late phase of inflammation. Peptide sequence analysis of the RM3/1 protein revealed similarity to CD163, a member of the scavenger receptor cysteine-rich family.

CD163 and inflammation: biological, diagnostic, and therapeutic aspects.

Anders Etzerodt et al.

Antioxidants & redox signaling, 18(17), 2352-2363 (2012-08-21)

The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages

Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer.

Haonan Lu et al.

Cell reports. Medicine, 4(7), 101092-101092 (2023-06-23)

Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm

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Global Trade Item Number

SKU	GTIN
163M-16	0841683125297
163M-18	0841683125310
163M-17	0841683125303
163M-15	0841683125280
163M-14	0841683125273
163M-16-RUO	04061836550318

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