16859
D-α-Hydroxyglutaric acid disodium salt
≥98.0% (GC)
Synonym(s):
(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate
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About This Item
Linear Formula:
C5H6O5Na2
CAS Number:
Molecular Weight:
192.08
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318041
Quality Level
assay
≥98.0% (GC)
form
powder or crystals
optical activity
[α]/D 8.5±1.5°, c = 1 in NaOH
impurities
≤6.0% water
storage temp.
2-8°C
SMILES string
[Na].O[C@H](CCC(O)=O)C(O)=O
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1
InChI key
DZHFTEDSQFPDPP-HWYNEVGZSA-L
Biochem/physiol Actions
Biomarker for inborn errors of metabolism and cancer
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Andrew J Worth et al.
Chemical research in toxicology, 28(5), 948-954 (2015-03-25)
The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG
Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase.
Whitman, C.P., et al.
Journal of the American Chemical Society, 114, 10104-10110 (1992)
Stereochemical studies on porphyrin a: assignment of the absolute configuration of a model porphyrin by degradation.
Battersby, A.R., et al.
Journal of the Chemical Society. Perkin Transactions 1, 9, 1565-1580 (1986)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 16859-50MG | 04061832393742 |
| 16859-10MG | 04061832393728 |
| 16859-250MG | 04061832393735 |