18726
Nα-Methyl-L-ornithine monohydrochloride
≥98% (TLC), powder
Synonym(s):
(S)-5-Amino-2-(methylamino)pentanoic acid hydrochloride, N-Me-Orn-OH · HCl
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About This Item
Empirical Formula (Hill Notation):
C6H14N2O2 · HCl
CAS Number:
Molecular Weight:
182.65
Beilstein:
6117952
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.32
Product Name
Nα-Methyl-L-ornithine monohydrochloride, ≥98% (TLC)
Quality Level
Assay
≥98% (TLC)
form
powder
optical activity
[α]/D +27.0±1.0°, c = 1 in 1 M HCl
composition
carbon, 38.7-40.2%
nitrogen, 14.9-15.7%
SMILES string
Cl.CN[C@@H](CCCN)C(O)=O
InChI
1S/C6H14N2O2.ClH/c1-8-5(6(9)10)3-2-4-7;/h5,8H,2-4,7H2,1H3,(H,9,10);1H/t5-;/m0./s1
InChI key
OUPNMQRLBAANLP-JEDNCBNOSA-N
Biochem/physiol Actions
Nα-Methyl-L-ornithine has been identified as an inhibitor of nitric oxidase synthase in macrophages.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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T B McCall et al.
British journal of pharmacology, 102(1), 234-238 (1991-01-01)
1. The synthesis of nitric oxide (NO) from L-arginine by rat peritoneal neutrophils (PMN) and the murine macrophage cell-line J774 and the inhibition of this synthesis by N-iminoethyl-L-ornithine (L-NIO), NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine (L-NNA) and its methyl ester (L-NAME) were investigated.
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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